Progent 10%

Gentamycin is an antibiotic belonging to the group of amino-glycosides. It has bactericidal activity against Gram-positive and Gram-negative bacteria (including: Pseudomonas spp., Klebsiella spp., Enterobacter spp., Serratia spp., E. coli, Proteus spp., Salmonella spp., Staphylococci). Furthermore, it is active against Campylobacter fetus subsp. jejuni and Treponema hyodysenteriae. Gentamycin may be active against bacteria which are resistant to other amino-glycoside antibiotics (like neomycin, streptomycin, and kanamycin). After intramuscular administration, within 30 – 60 minutes’ maximum serum concentrations are obtained. Gentamycin is excreted mainly by the kidneys, resulting in high concentrations of the active compound in the urine.

Indications

Progent Injectable Solution is used for the treatment of respiratory, gastrointestinal, urogenital system infections and other soft tissue infections caused by gentamicin-sensitive bacteria in cattle, horses, swine, cats and dogs.

Administration and Dosage

For intramuscular or intravenous injection:
Pharmacological dose is 4 mg / kg bodyweight for the target species.

Species	Therapeutic Dose
Cattle, Horses	4 mL / 100 kg bodyweight / day
Heifers	2 mL / 50 kg bodyweight / day
Calves, Foals	1 mL / 25 kg bodyweight / day
Swine	1 – 2 mL / 50 kg bodyweight / day
Cats, Dogs	0.2 mL / 5 kg bodyweight / day

Note
The treatment is continued for 2-3 days.

Cautions
Cattle and swine kept for meat must not be sent to slaughter throughout the treatment and within 7 days following the last drug administration. Milk of animals obtained throughout the treatment and within 3 days (6 milking) following the last drug administration should not be offered to consumption by human

Contra indications

Do not administer to animals hypersensitive to amino-glycoside antibiotics. Do not administer to animals with an impaired renal function or with vestibular, ear or visual dysfunctions. Do not use in animals in lactation if milk is intended for human consumption.

Side effects

Kidney damage and/or toxicity, with the vestibular function most often being damaged, when given at high doses and during long times. Respiratory paralysis due to neuromuscular blockade (at very high doses) may occur.

Incompatibility with other drugs 

Do not combine with potential nephrotoxic or muscle paralyzing medicines.

Withdrawal Period

Meat:

• Cattle, sheep, goats: 90 days
• Pigs: 40 days

Storage

Store in a cool, dry place, protected from light. Store among 15º to 30ºC.

Keep medicine away from children and domestic animals.

Target Species

Cattle, horses, swine, dogs and cats.

Presentation

Multidose vials of 100 mL.